Vol. 1, Issue 4 (2016)
Behavioural effects of methanol stem bark extract of Ficus sycomorus
Author(s): Tijani Adeniyi Yahaya, Salawu Oluwakanyinsola Adeola, Fidelis Solomon Ameh, Ahmadu Peter Uchogu
Abstract: Background: Neuropsychiatric disorders are characterized by anxiety, altered locomotion and altered sleep pattern characterized by insomnia. Ficus sycomorus is a widely used medicinal plant used locally in Northern Nigeria for calming agitated patients. Aim: The aim of the current study was to provide scientific evidence to support its continuous use in the management of neuropsychiatric conditions. Methods: The effect of Ficus sycomoros stem bark extract (50, 100 and 200 mg/kg body weight orally), Normal saline (l0 ml/kg orally) and diazepam (1 mg/kg body weight orally) on anxiety in mice were evaluated on Elevated plus Maze (EPM), Elevated Zero Maze (EZM) and Open Field Apparatus (OFA). Results: The extract at doses of 50,100 mg/kg body weight and diazepam (2.5 mg/kg orally) produced significant (p<0.05) increase in time spent in the opened arm of Elevated plus Maze and Elevated Zero Maze when compared to Normal saline treated control. At 200 mg/kg body weight orally the extract paradoxically produced significant (p<0.05) increase in time spent by treated mice in the closed arm of Elevated Plus Maze and Elevated Zero Maze when compared to Normal saline treated control. The extract at 50, 100 mg/kg body weight orally and diazepam (2.5 mg/kg body weight orally) produced anxiolytic-like effects in treated mice on the open field apparatus. At 200 mg/kg body weight orally the extract produced sedative-like effects on treated mice in the opened field apparatus. Conclusion: Ficus sycomoros stem bark extract possesses anxiolytic activity in mice which may be explored further for leads in the development of potent safe and effective anxiolytic agent for human use.