Vol. 1, Issue 4 (2016)
Formulation and development of hepato-protective butea monosperma-Phytosome
Author(s): Gahandule MB, Dr. Jadhav SJ, Dr. Gadhave MV, Dr. Gaikwad DD
Abstract: The flower of butea monosperma having traditionally use as treatment of diabetes and hepatoprotective activity. The Butea monosperma has limited gastrointestinal absorption because of its low bioavailability. Different flavonoids are slowly absorbed because the multi-ring compound. Many flavonoids they can cross lipid rich outer memberane of small intestine. The aquous Extract of phytosome were prepared in soya lecithin. Soya lecithin has antioxidant activity. Evaluation of phytosome for solubility study, Entrapment efficiency Transition temperature, X-ray diffraction, In vitro dissolution studies, FTIR study, an in vitro radica lsavenging activity by DPPH model Combination of soya lecithin and butea monosperma can result in synergistic effect, Synergistic effect measure with free radical scavenging activity use DPPH MODEL. Formulation of phytosome they can be loaded into capsule dosage form.
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