Vol. 1, Issue 5 (2016)
Evaluation of anticonvulsant activity of aqueous root extract of Cocos Nucifera linn. In mice
Author(s): K. Usha Rani, P. Venkateswara Rao, S. Lal Basha, J. Dhana Lakshmi, B. Ganesh, B. Sireesha, G. Indraja
Abstract: The Present study was undertaken to investigate the Anticonvulsant activity of aqueous root extract of Cocos nucifera Linn. (arecaceae) on mechanically induced seizures in mice. The aqueous root extract of Cocos nucifera (ARECN) was studied for its anticonvulsant activity by using experimental paradigms like Maximal electroshock-induced seizures (MES). ARECN exhibited protection against tonic convulsions induced by MES in swiss albino mice. It was found that the extract (50 & 100 mg/kg, p.o), significantly prolonged the onset of tonic seizures and reduced the duration of incidence of seizures in MES induced seizure models. These findings suggest that aqueous root extract of Cocos nucifera (L.) produce its anticonvulsant activity by enhancing GABA inhibitory neurotransmission, since it delayed the latency of tonic seizures and duration of seizures produced by PTZ and PIC.