Synthesis and characterisation of pyrazole derivatives from para bromo benzoic acid and its antibacterial activity
Arathi Prakash, Jessy Jacob
Pyrazole is an organic compound with the formula C3H3N2H. It is a heterocycle characterized by a 5-membered ring of three carbon atoms and two adjacent nitrogen atoms. Numerous pyrazole derivatives have been found to possess a broad spectrum of biological activities like anti-bacterial, anti-convulsant, analgesic, anti-microbial, anti-inflammatory, anti-diabetic, sedative anti-rheumatic, anticancer, and anti-tubercular activities. The compounds were synthesized by the normal conventional technique in the lab. All the synthesized compounds were screened for antibacterial activities at three different concentrations (100µg/ml, 250µg/ml, 500µg/ml) against Pseudomonas aeruginosa (Gram –ve) and Bacillus subtilis (Gram + ve) by cup plate agar diffusion method and MIC was found out.