International Journal of Research in Pharmacy and Pharmaceutical Sciences

International Journal of Research in Pharmacy and Pharmaceutical Sciences


International Journal of Research in Pharmacy and Pharmaceutical Sciences
International Journal of Research in Pharmacy and Pharmaceutical Sciences
Vol. 4, Issue 3 (2019)

Impact of valsartan on some renal function parameters in hypertensive patients


Hayder S Hussein, Nusieba A Mohammed Ibrahim

Objective: The main aim of this current research study was to test the effect of valsartan on some renal function parameters (RFPs) in some hypertensive patients. Materials and Methods: This study was conducted in Nablus Hospital, Department of Internal Medicine, Mosul, Iraq, on 20 hypertensive patients. They were recruited and investigated for RFPs, which include: blood urea, serum creatinine, creatinine clearance, serum Na+, and serum K+. The patient (valsartan) group was followed-up for 8 weeks, during which RFPs were measured before starting therapy and at the end of the follow-up period using commercially available kits. The patient group was compared with a control group consisted of 30 healthy subjects. Results: The RFPs at baseline (before valsartan administration) in the patient group were found elevated as compared to the control group (p<0.001), except for serum K+ concentration, which was comparable. The RFPs in the patient group were similar before and after therapy. Conclusion: The use of valsartan for 8 weeks in some hypertensive patients had no adverse effects on RFPs.
Pages : 65-67