Novel drug delivery system (NDDS) and nanoscience are widely seen as having a tremendous promise to revolutionize the scientific landscape in terms of research and applications. Among various approaches for development of NDDS for biomedical applications, carriers offer great advantages in drug delivery, sensing and imaging. Proliposomes are used as alternatives for liposomes which are composed of water soluble porous powder as carrier phospholipids and drugs dissolved in organic solvent. Drug and phospholipid material is coated on carrier material to form free flowing granular material which shows better stability, greater solubility and shows controlled release.The proliposome approach was developed as a straight forward, reproducible, and reliable manufacturing technique for large-scale production of liposome dispersions. The technology is based upon the intrinsic property of hydrated membrane lipids to form vesicles on contact with water. It is designed particularly for the molecular dispersion and delivery of water-insoluble materials where association efficiencies approaching 100% can be achieved.