Objective: This research was aimed at to design, develop and evaluate fast dissolving tablets of montelukast sodium using synthetic superdisintegrants at variable concentrations. Methods: In the present study, the fast dissolving tablets of Montelukast Sodium were formulated using direct compression method incorporating microcrystalline cellulose (MCC) as direct compressible diluents after finding encouraging results of prefomulation studies. Sodium starch glycolate (SSG) and Croscarmellose sodium (CCS) were selected as synthetic superdisintegrants seeing their high swelling index. Ten formulations were prepared using varied concentrations of superdisintegrants. The investigations of these formulations were aimed to look into their influence on the disintegration time and dissolution rate of these tablets and other evaluation parameters were also evaluated. Results: Fast dissolving tablets of montelukast sodium were prepared with croscarmellose sodium (7.5 mg) had a shorter disintegration time and gives the best pharmaceutical performance. The evaluation of formulations reflected good pre and post-compressive characteristics. Conclusion: The result obtained in this research work clearly shows that a promising potential of fast dissolving tablets of montelukast sodium containing croscarmellose sodium as a result of faster dissolution leading to possibilities of faster onset of action in asthma attack may be beneficial.