Formulation and evaluation of fast dissolving tablets of losartan potassium by using superdisintegrant crosspovidone and its kneading mixture
Jitender Mor, Rajinder Mann, Satish Kumar
Fast dissolving tablets are those when put on tongue disintegrate instantaneously releasing the drug which dissolve or disperses in the saliva. Superdisintegrants are agents added to tablet formulations to promote the breakup of the tablet into smaller fragments in an aqueous environment thereby increasing the available surface area and promoting a more rapid release of the drug. A disintegrant used in granulated formulation processes can be more effective if used both “intragranularly” and “extragranularly” thereby acting to break the tablet up into granules and having the granules further disintegrate to release the drug substance into solution. Losartan potassium tablet were designed with a view to enhance the patient compliance and provide a quick onset of action. Losartan potassium is used in the management of hypertension. It has low bioavailability due to its first pass metabolism. The main objective of the present work was to enhance the solubility, dissolution rate and bioavailability of Losartan potassium by preparing its kneading mixture with crosspovidone in order to develop its fast dissolving tablets. In the first step crosspovidone was examined for suitability as solubility enhancer in kneading method. The characteristics of different kneading mixture samples were compared to the respective physical mixtures and active pharmaceutical ingredient to access the effect of various processes. Further it was evaluated which technique is better. The solid state of kneading mixture was evaluated with infrared spectroscopy and was correlated with in-vitro dissolution behavior.