International Journal of Research in Pharmacy and Pharmaceutical Sciences

Authors
Dr. C Girish, Y Narsimha Reddy

Abstract
The purpose of the study was to test the acute oral toxicity of the different extracts of the plant Leptadenia reticulata. Acute toxicity of petroleum ether, methanol and aqueous extracts of Leptadenia reticulata was evaluated in Swiss mice. The acute toxicity studies were carried out based on OECD guidelines 423. The animals were orally administered with a single dose of 100, 250, 500, 750, 1000, 2000mg/kg body weight of each extract. Signs of toxicity and mortality were noted after 1, 4 and 24h of administration of the extract for 14 days. The highest dose administered (2000mg/kg body weight) did not produce mortality or changes in general behaviour of the test animals. These results indicate the safety of the oral administration of petroleum ether, methanol and aqueous extracts of Leptadenia reticulata.