A simple, specific, precise and accurate revere phase liquid chromatography method has been developed for estimation of Escitalopram oxalate and Clonazepam in solid dosage forms. The chromatographic separation was achieved on a 5 – micron C 18 column (250x 4.6mm) using a mobile phase consisting of a mixture of ORTHO PHOSPHORIC ACID pH 6: Acetonitrile: Methanol (55:20:25 % v/v) was used pH 6.0 The flow rate was maintained at 1.0 ml / min. The detection of the constituents was done using UV detector at 220 nm for Escitalopram oxalate and Clonazepam. The retention time of Escitalopram oxalate and Clonazepam found is eluted 4.06 and 6.34minutes min respectively. The developed method was validated for accuracy, linearity, precision, limit of detection (LOD) and limit of quantification (LOQ) and robustness as per the ICH guidelines.