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VOL. 1, ISSUE 1 (2016)
Preparation and evaluation of sustained release film: Coated tablets of nitrofurantoin
Authors
Ayush Garg, Anshu Sharma, Indrajeet Singhvi
Abstract
Sustained release drug delivery system offer advantages of attenuation of adverse effects, fewer fluctuations in plasma drug concentration, improved patient compliance, reduction in dosing frequency, etc. The present study attempt has been made to develop and evaluate sustained release film-coated tablets of nitrofurantoin. The designing of sustained release tablets was done using wet granulation technique and the polymers were used in varying proportions. The tablets were prepared using polymers such as HPMC K100M, HPMC E15 and different excipients. The prepared tablets were evaluated for hardness, friability, thickness, weight variation, drug content and in vitro dissolution studies. The mean values of the results of various evaluation parameters were statistically presented by plotting graphs. The in vitro release data were fitted into zero-order, first order, Higuchi and Korsemeyer-Peppas models. All formulated tablets showed acceptable pharmacotechnical properties and complies with pharmacopoeial specifications but batch F6 shows better results and release than other formulated tablets. The in-vitro release data was plotted for formulation F6 which indicates that drug release was governed by nearly zero-order kinetics. Formulation F6 showed no change in physical appearance, drug content after storage 40 0C±2 0C / 75% RH ± 5% for 3 months. Further, in-vivo and continuation of stability studies are recommended.
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Pages:47-53
How to cite this article:
Ayush Garg, Anshu Sharma, Indrajeet Singhvi "Preparation and evaluation of sustained release film: Coated tablets of nitrofurantoin". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 1, Issue 1, 2016, Pages 47-53
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