International Journal of Research in Pharmacy and Pharmaceutical Sciences

International Journal of Research in Pharmacy and Pharmaceutical Sciences


International Journal of Research in Pharmacy and Pharmaceutical Sciences
International Journal of Research in Pharmacy and Pharmaceutical Sciences
Vol. 1, Issue 2 (2016)

A review on recent trends in oral drug delivery- lyophilized wafer technology


Ghutukade Nagesh, Jadhav Santosh, Mali Audumbar, Patil Manojkumar

The lyophilized wafer technology is an effective and versatile drug delivery system for oromucosal application. This has been established from the extensive physicochemical and physicomechanical profiling conducted. Due to small size, little dose, thickness of buccal wafer over other dosage form is most acceptable and pleasant. Flash release oral wafer drug delivery system is an alternative approach for the tablets, capsules, and liquid oral dosage forms for pediatric and geriatric patients. The wafer system containing HPC, lactose, mannitol and glycine had the ability to disintegrate within 30 seconds. The modified wafer system, consisting of pectin cross linked with zinc ions serving as the drug reservoir, and mucoadhesive polymer combination of pectin, carmellose and gelatin, provided effective release of model drug diphenhydramine hydrochloride over approximately six hours. The semi-synthetic and synthetic natural polymer as film former in low concentration can be used for the preparation of Buccal wafers and hence such dosage form are easy to handle, cost effective, fast absorbable, non- irritating and mostly preferred by patient. It improve the efficacy of APIs by dissolving within minute in oral cavity after the contact with less saliva as compared to fast dissolving tablets, without chewing and no need of water for administration. Present article overview the advancement in the oral dosage forms, application, formulation composition, method of preparation, evaluation and marketed products of oral flash release wafers.
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