International Journal of Research in Pharmacy and Pharmaceutical Sciences

International Journal of Research in Pharmacy and Pharmaceutical Sciences


International Journal of Research in Pharmacy and Pharmaceutical Sciences
International Journal of Research in Pharmacy and Pharmaceutical Sciences
Vol. 1, Issue 2 (2016)

Spectrophotometric simultaneous estimation and validation of drotaverine hydrochloride and in tablet dosage form using various methods


Raj K Prasad, Vidyakant Kushwaha, Suresh Nair, Vivek Dwivedi

Three simple, sensitive and accurate UV spectrophotometric methods, I; formation and solving of simultaneous equation method, II; absorbance ratio method, III; dual wave length method, has been developed for the determination of drotaverine hydrochloride and nimesulide in tablets dosage form. Beers’ law was obeyed in the concentration range 5-35 µgml-1 and 10-50 µgml-1 for drotaverine (λmax = 230.5 nm) and nimesulide (λmax = 331.5 nm) respectively in methanol. All the three methods allowed rapid analysis of binary pharmaceutical formulation with accuracy. Results of analysis for three methods were tested and validated for various parameters according to ICH guidelines.
Pages : 01-04 | 1651 Views | 770 Downloads