Three simple, sensitive and accurate UV spectrophotometric methods, I; formation and solving of simultaneous equation method, II; absorbance ratio method, III; dual wave length method, has been developed for the determination of drotaverine hydrochloride and nimesulide in tablets dosage form. Beers’ law was obeyed in the concentration range 5-35 µgml^-1 and 10-50 µgml^-1 for drotaverine (λmax = 230.5 nm) and nimesulide (λmax = 331.5 nm) respectively in methanol. All the three methods allowed rapid analysis of binary pharmaceutical formulation with accuracy. Results of analysis for three methods were tested and validated for various parameters according to ICH guidelines.