International Journal of Research in Pharmacy and Pharmaceutical Sciences

International Journal of Research in Pharmacy and Pharmaceutical Sciences


International Journal of Research in Pharmacy and Pharmaceutical Sciences
International Journal of Research in Pharmacy and Pharmaceutical Sciences
Vol. 1, Issue 2 (2016)

Efficacy of different leaf extract fractions of Prunus cerasoides D. Don on benign prostate hyperplasia


Sarma Dhrubajyoti

Benign prostatic hyperplasia (BPH) is a common problem of aging for men. The most serious cases of BPH may be treated surgically. In addition to allopathy, traditional herbs were used as drugs against prostate diseases in ancient and folkfore systems. Various formulations of P.cerasoides listed in ancient and folkfore literature. Several Preliminary studies are carried out for its use as in prostate and genitourinary disorders, which require a systemic study and evaluation of for its use. Here, an attempt has been made to evaluate the beneficial effects of P.cerasoides on prostate and urinary disorders. Leaves of P.cerasoides were collected from Shillong, Meghalaya.

The methanolic extract of the plant was fractionated by column chromatography. For in-vivo studies, wistar male rats were divided into groups, first group received propylene glycol (0.2 ml/rat i.p.), second group received testosterone (0.2 mg/rat s.c.), third group received testosterone with plant extract (10 mg/kg body weight, i.p.) and the last group received testosterone with standard drug (Finasteride). One group of uncastrated rat received propylene glycol (0.2ml/rat i.p.). After 30 days all the animals were sacrificed under anesthesia and the total prostate weight was measured for all the animals. Plant extract significantly decreased the testosterone induced prostate weight.
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