Recently, fast dissolving drug delivery systems have started gaining popularity and acceptance as new drug delivery systems, because they are easy to administer and leads to better patient compliance. These delivery systems either dissolves or disintegrate in mouth rapidly, without requiring any water to aid in swallowing. They also impart unique product differentiation, thus enabling use as line extensions for existing commercial product. These novel drug delivery systems can also be beneficial for meeting the current needs of the industry as improved solubility, stability and bioavailability of drugs. Although oral disintegrating tablets have an advantage of administration without chocking and fast disintegration; the disintegrated materials contained in them are insoluble and remain until swallowing. In such case formulation of fast dissolving films will be advantageous. In the present work, an attempt was made to prepare and evaluate oral fast dissolving films of lisinopril for effective management of hypertension and cardiac disease. Lisinopril fast dissolving films were formulated by using natural and synthetic polymers by solvent casting method. Drug- excipient interactions were studied by FTIR. Oral films were evaluated for surface pH, mechanical strength, thickness, folding endurance, tensile strength and in- vitro release profile.