Proniosomes are the dry formulations of surfactant-coated carrier, which can be measured out as and rehydrated by brief agitation in hot water immediately before use to yield aqueous niosome dispersion similar to those prepared by conventional method. These proniosomes minimize problem of physical stability of niosomes such as aggregation, fusion and leaking and convenience in transportation, distribution, storage and daosing. Proniosomes can be converted into niosomes upon simple hydration of the skin so proniosomes offer a versatile vesicle delivery concept with the potential for delivering drug via the topical/transdermal rout.