For the past few decades, there has been a considerable research carried out in the field of Nanotechnology especially in the area of drug delivery using particulate delivery systems as carriers for small and large molecules. Nanotechnology in the form of nanoparticles has great potential in the drug delivery field. A poorly water-soluble drug indicates insufficient bioavailability following oral administration, resulting in fluctuating plasma level. Nanosuspensions of poorly water-soluble drugs are known to increase the oral bioavailability. In the present work, Cisapride nanosuspension was prepared by Precipitation technique using Tween 80 as stabiliser. Formulation 5 was the best formulation with a % Entrapment Efficiency of 93.42%, % Drug Release of 95.6%, Zeta Potential of -17.3mV, Polydispersity of 0.222 and Particle Size of 438nm. Thus Formulation 5 was selected as the optimised formulation.