Plants have played an important role in human health care since the ancient times and paved path for the discovery of novel drugs. In the present study the pharmacological activities (anti-inflammatory, anti-pyretic and anti-analgesic activity) of chloroform, methanol and aqueous extracts of Andrographis paniculata was evaluated to emphasize the potential of herbal components in the field of medical science to cure various dreadful diseases. In order to assess anti-analgesic, anti-pyretic and anti-inflammatory activity, hot water induced analgesic, yeast induced pyrexia and carageenan induced paw oedema was used respectively in rat. In all cases 200mg/kg.p.o of A. paniculata extracts were administrated to the Wistar albino rats and the results were compared with control (1ml/kg normal saline). Statistically significant results were obtained in anti-analgesic (PË‚0.05), anti-inflammatory (PË‚0.001) and anti-pyretic activity of chloroform, methanol and aqueous extract of A. paniculata. Hence, this study emphasized the potential pharmacological activity of chloroform, methanol and aqueous extracts of A. paniculata.