Proniosomes are dry formulations of surfactant-coated carrier, which can be measured out as needed and rehydrated by brief agitation in hot water. These “proniosomes” minimize problems of niosomes physical stability such as aggregation, fusion and leaking and provided additional convenience in transportation, distribution, storage and dosing. Maltodextrin and Mannitol has been used as carriers for the preparation of Various Proniosome powder formulations by slurry method. Niosomes derived from Proniosomes of both carriers were compared in terms of morphology, vesicle size, entrapment efficiency and in vitro drug release. Meloxicam used as model drug. Average particle was found to be in range of 6.943 to 7.258 μm for Maltodextrin and from 5.919 to 7.026 μm for Mannitol. Percentage cumulative drug release was higher in maltodextrin as compared to mannitol while entrapment efficiency was less in Mannitol as compared to Maltodextrin. Thus it can be concluded that Mannitol can be used as suitable carrier for preparation of proniosomes.