Pyrimidine is the aromatic heterocyclic organic compound. It has the three diazines, six membered heterocyclic with two nitrogen atom in the ring & also have nitrogen atoms in the positions 1 or 3 in the ring and also present in the nucleic acids, three types of the nucleobases derivatives cytosine (C), Thymine (T), & Uracil (U). In this article we explore the synthesis of drug Doxorubicin, Galanthamine, Narwedine, Haementadine & (Z)-& (E)-2, 2 [Bis (hydroxymethyl) cyclopropylidene] methylpurins & Pyrimidine. Also describe the anticancer activity of some doxorubicin derivatives because the doxorubicin derivative shows anticancer activity. Thymidine ring also show the anticancer activity so we choose the both of the ring & also check the anticancer activity.