Analysis of cadmium chloride toxicity in rats and its amelioration with Murraya koenigii leaves extracts
Gaurav Yadav, Arti Saxena
Objective: The main objective of this study was to examine the protective action of aqueous extract of Murraya koenigii against cadmium chloride toxicity in wistar albino rats.
Methods: for in vivo analysis, albino rats were divided into four groups. Control, CuLE (Curry leaf extract) treated, cadmium treated and aqueous extract protected groups. The rats were treated with 6.5 mg/kg body weight cadmium chloride intraperitoneally. And oral route of administration was preferred for curry leaf extract administration.
Results: Increased levels of serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase enzymes (SGPT) were recorded. The level of antioxidant enzymes, Superoxide dismutase and Catalase were also found altered with the exposure of cadmium chloride. All these changes were ameliorative when the rats were treated with curry leaf extract.
Conclusion: Based on the findings we may conclude that aqueous extract of Murraya koenigii can provide complete protection against cadmium chloride toxicity in rats.
Gaurav Yadav, Arti Saxena. Analysis of cadmium chloride toxicity in rats and its amelioration with Murraya koenigii leaves extracts. International Journal of Research in Pharmacy and Pharmaceutical Sciences, Volume 2, Issue 3, 2017, Pages 57-62