International Journal of Research in Pharmacy and Pharmaceutical Sciences

International Journal of Research in Pharmacy and Pharmaceutical Sciences


International Journal of Research in Pharmacy and Pharmaceutical Sciences
International Journal of Research in Pharmacy and Pharmaceutical Sciences
Vol. 2, Issue 3 (2017)

Analysis of cadmium chloride toxicity in rats and its amelioration with Murraya koenigii leaves extracts


Gaurav Yadav, Arti Saxena

Objective: The main objective of this study was to examine the protective action of aqueous extract of Murraya koenigii against cadmium chloride toxicity in wistar albino rats.
Methods: for in vivo analysis, albino rats were divided into four groups. Control, CuLE (Curry leaf extract) treated, cadmium treated and aqueous extract protected groups. The rats were treated with 6.5 mg/kg body weight cadmium chloride intraperitoneally. And oral route of administration was preferred for curry leaf extract administration.
Results: Increased levels of serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase enzymes (SGPT) were recorded. The level of antioxidant enzymes, Superoxide dismutase and Catalase were also found altered with the exposure of cadmium chloride. All these changes were ameliorative when the rats were treated with curry leaf extract.
Conclusion: Based on the findings we may conclude that aqueous extract of Murraya koenigii can provide complete protection against cadmium chloride toxicity in rats.
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How to cite this article:
Gaurav Yadav, Arti Saxena. Analysis of cadmium chloride toxicity in rats and its amelioration with Murraya koenigii leaves extracts. International Journal of Research in Pharmacy and Pharmaceutical Sciences, Volume 2, Issue 3, 2017, Pages 57-62
International Journal of Research in Pharmacy and Pharmaceutical Sciences