International Journal of Research in Pharmacy and Pharmaceutical Sciences

International Journal of Research in Pharmacy and Pharmaceutical Sciences


International Journal of Research in Pharmacy and Pharmaceutical Sciences
International Journal of Research in Pharmacy and Pharmaceutical Sciences
Vol. 2, Issue 3 (2017)

Importance of Matrix Metalloproteinases (MMP) in cancer Progression with production of Human Monoclonal antibodies: A short review


Chandan Singh Ahirwar, AK Pathak

Cancer is one of the leading causes of disease and mortality worldwide. As a result, the past two decades of biomedical research have yielded an enormous amount of information on the molecular events that take place during carcinogenesis and the signaling pathways participating in cancer progression. Matrix metalloproteinases (MMPs) consist of a multigene family of zinc-dependent extracellular matrix (ECM) remodeling endopeptidases implicated in pathological processes, such as carcinogenesis. In this regard, their activity plays a pivotal role in tumor growth and the multistep processes of invasion and metastasis, including proteolytic degradation of ECM, alteration of the cell–cell and cell–ECM interactions, migration and angiogenesis. MMPs are therefore amenable to therapeutic intervention by synthetic and natural inhibitors, providing perspectives for future studies.
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How to cite this article:
Chandan Singh Ahirwar, AK Pathak. Importance of Matrix Metalloproteinases (MMP) in cancer Progression with production of Human Monoclonal antibodies: A short review. International Journal of Research in Pharmacy and Pharmaceutical Sciences, Volume 2, Issue 3, 2017, Pages 75-77
International Journal of Research in Pharmacy and Pharmaceutical Sciences