High blood pressure (HTA), which was once considered a rare disease in Black Africa, is today experiencing a dazzling and worrying progression mainly due to its complications. In Africa, HTA affects about 10 to 17 % of the population. In Côte d'Ivoire, this prevalence is estimated to be between 7 and 13 %. Because of the generally high costs of antihypertensive treatments based on modern medicines, in the context of the valorization of traditional medicine, we evaluated the pharmacological effect of the leaf decoctate of Tridax procumbens, a plant used for the treatment of high blood pressure. Phytochemical trials carried out to the leaves of this plant revealed the presence of stress and polyterpenes, polyphenols, flavonoids, tannins, saponosides and alkaloids. The pharmacological study showed that leaves aqueous extract of T. procumbens is endowed with hypotensive properties which are linked to the phytochemical constituents found in the leaves.