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VOL. 2, ISSUE 5 (2017)
GC-MS analysis and antimicrobial activity of Sudanese Ruta graveolens L. (Rutaceae) fixed oil
Authors
Abdel Karim M, Allaa A, Khalid MS
Abstract
The present study was designed to investigate the chemical constituents of Ruta graveolens Linn. Seed oil and to assess its antimicrobial activity. Forty four components were detected by GC-MS analysis. Major components are: 9,12-octadecadienoic acid methyl ester(27.79%); 9,12,15-octadecatrienoic acid methyl ester(14.79%); hexadecanoic acid methyl ester(11.29%); methyl stearate(7.49%); 1,4-dihydroxy-3-(3-methyl-2-butenyl) - 2-naphthalenecarboxylic acid (7.04%); 9-octacecenoic acid methyl ester (5.43%).
The antimicrobial activity of the oil was evaluated using the diffusion assay against: Gram positive: Staphylococcus aureus and Bacillus subtilis; Gram negative: Escherichia coli and Pseudomonasa aeruginosa and the fungi Candida albicans and Aspergillus niger. The oil showed excellent activity against Bacillus subtilis at all test concentrations. It also gave significant activity against all test organisms in the range: 100-50mg/ml.
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Pages:29-33
How to cite this article:
Abdel Karim M, Allaa A, Khalid MS "GC-MS analysis and antimicrobial activity of Sudanese <em>Ruta graveolens</em> L. (Rutaceae) fixed oil". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 2, Issue 5, 2017, Pages 29-33
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