Cinnoline (1, 2 benzodiazine or pyridine) is a novel aromatic bioactive heterocyclic compound which have wide range of pharmacological profiles like antimicrobial activity like antibacterial, antifungal, anti-inflammatory, antihelminthic activity, anti molluscicidal activity, antimalarial, anti-tuberculosis, anti tumor activity etc. Cinnoline has a heterocyclic system, which is fused six member ring containing two nitrogen atoms with special structural activity have been showed special interest in chemical or synthetic research field. This review critically discusses about the synthesis, wide range of activities and applications of Cinnoline aromatic compound. Apart from that, this review is also enlisted the various reported literature based on advanced synthesis and application of Cinnoline in various biological activities.