Valsartan is an angiotensin II receptor antagonist (ARB), which is selective for the type I (AT1) angiotensin receptors. It act by blocking the action of angiotensin II which reduce blood pressure by constricting blood vessels and activating aldosterone. Different Chromatographic methods are available for single and combination with other drugs. Most of Methods were of RP-HPLC, LC and HPTLC because these methods provided with best available reliability, repeatability, analysis time and sensitivity.