Sumatriptan is use for the migraine with and without aura and for cluster headaches. It is a 5-Hydroxy tryptamine (5-HT) receptor agonist type (5-HT1B and 5-HT1D). Promethazine is an antiemetic drug belonging to the class of Phenothiazine. Sumatriptan plus Promethazine was proved to be effective at a dose of 50mg and 25mg in management of migraine compare to the Sumatriptan monotherapy. Addition of Promethazine to Sumatriptan was proved effective in relief of nausea and vomiting, rate of pain recurrence reduced with significant improvement in the headache free rate. A triptan plus antiemetic showed the effective results in relief of the migraine associated Headache, Nausea, Vomiting, Photophobia and Phonophobia.