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VOL. 3, ISSUE 1 (2018)
GC-MS analysis and antimicrobial activity of Piper longum Linn. fixed oil
Authors
Abdel Karim M, Rayan A Mohamed K
Abstract
The present study was carried out to investigate the chemical constituents of Piper longum Linn. seed oil and to assess its antimicrobial activity. 118 components were detected by GC-MS analysis. Major components are: cubedol (9.93%), 2,4-diphenyl-6-(2-hydroxy-3-tolyl)pyrimidine (8.42%), 2-[2,4-dimethoxybenzylidene]-2H-thiazole(3.36%), chloroacetic acid dodec-9-ynyl ester (3.12%), shyobunone (3.00%).
The antimicrobial activity of the oil was evaluated using the diffusion bioassay against: (Gram positive: Staphylococcus aureus and Bacillus subtilis; Gram negative: Escherichia coli and Pseudomonasa aeruginosa and the fungi Candida albicans and Aspergillus niger) The oil showed significant activity against Staphylococcus aureus at 100 and 50mg/ml. It also revealed excellent activity against Escherichia coli at 100μg/ml. However, only a partial activity was shown against the yeast Candida albicans in the range: 100-25mg/ml.It seems that the oil is a lead for further optimization.
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Pages:133-139
How to cite this article:
Abdel Karim M, Rayan A Mohamed K "GC-MS analysis and antimicrobial activity of <em>Piper longum</em> Linn. fixed oil". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 3, Issue 1, 2018, Pages 133-139
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