At the present work a simultaneous Determination of Bisoprolol fumarate and Hydrochlorothiazide Multi-component Products, examining System Suitability, Specificity, Linearity and Accuracy via RP-HPLC method was carried out. The separation was achieved using Cyanide column (250 × 4.6mm, 5μm particle size), both components were determined by UV detector at fixed wavelength at 228nm, for simplicity of the method an isocratic elution was selected, the optimized mobile phase was composed of methanol and buffer solution (pH=5.0) at 82:18 ratio, with flow rate of 0.9ml/min, injection volume was 10μl, and the separation was performed at 30 ^ͦ C. Plot of average area versus prepared concentrations indicates a very good linearity correlation for, (R² =0.999) for both components. The limit of detection for bisoprolol fumarate and hydrochlorothiazide was found to be 1.8575μg/ml and 3.57811μg/ml, respectively; whereas the limit of quantitation was found to be 6.19184 μg/ml and 11.92μg/ml; respectively. The proposed method was found to be specific and accurate.