The ability of a dosage form to deliver the medicament at the site of action is the most important parameter in order for a drug to show the desired action. The quality of a dosage form is quite important as it determines the safety and efficacy of the active constituent present in it. The method of preparation of a dosage form varies from manufacturer to manufacturer hence it can be assumed that their efficacy is likely to be varied. The present study was carried out in order to evaluate the quality of two brands of Dexamethasone Tablets IP 0.5 mg available commercially whether they qualify the entire test as mentioned in Indian Pharmacopoeia which there by suggests their quality and efficacy for use among the population. The study was exclusively experimental that used Indian Pharmacopoeia 2014 to check the in vitro quality of Dexamethasone Tablets IP using different analytical techniques and procedure. All the two brands under the study were within the specification for weight variation test for tablet. The test for Assay and uniformity of content carried out by High Performance Liquid Chromatography using U-HPLC System (Thermo- Dionex) equipped with an UV detector and stainless steel column (20cm × 5mm) packed with octadecylsilane chemically bonded to porous silica. Identification test was done by infrared absorption spectrophotometry, by comparing the spectrum with that obtained with Dexamethasone RS. The present research work indicated that two different brands which were examined did not show much difference in their results and they were found to be within the acceptance limits.