Introduction: The purpose of this study was to assess problems related with self – medication with antibiotics and analgesics in Freetown. Objectives: The objective of the study was to identify the frequency of occurrence of various MRPs, their causes and the demographic factors influencing drug choice and mrps Method: The study was done using an adapted version Pharmaceutical Care Network of Europe (PCNE) Classification System as instrument. The classification is for use in research into the nature, prevalence, and incidence of MRPs and also as a process indicator in experimental studies of Pharmaceutical Care outcomes. A sample of 282 respondents was taken using convenient sample method.the instrument was administered in a personal interview Ethical approval was obtained from the Research and Ethics Committee of the College of Medicine and Allied Health Sciences – Freetown. Results obtained:Drug choice problems accounted for 76 % of MRPs. A good number of participants selected a medication that was inappropriate (64.5%) and a significant proportion of participants (47.2 percent) were insufficiently aware of health and diseases. Erroneous assumptions were common. Inappropriate drug and insufficient awareness of health and diseases were very frequently occurring problems. Discussion: It was evident from this study that a lot of irrational drug use occurs in self-medication. People hold strong unscientific and in some cases totally irrational perceptions on the uses, doses, effects of various medications. A total number of 184 cases were resolved, showing that, where problems could be identified, the interventions were effective and that drug related problems can be minimized via effective counseling and pharmaceutical care. Conclusion: It was concluded from the study that MRPs abound in self-medication even amongst educated people, but the availability of health care professionals who are ready to render pharmaceutical care and counselling can significantly minimize the occurrence.