This paper represents the antimicrobial potentialities of the crude rhizomatous extract of Curcuma aromatica Salisb. and leaf extract of Ixora coccinea L. First, the crude extract from two different plants were taken separately for antimicrbial screening and then both the extract used simultaneously to evaluate the better efficiency of the herbal formulation. The extract mixture shows higher efficiency in respect to antimicrobial potentiality than either of the plant when used solely. After that, I performed sequential solvent partitioning of the extract mixture to locate which fraction actually carries the antimicrobial one. Diethyl ether fraction was found to contain some bioactive phytochemical(s) that can be of ecofriendly crop protectant.