Lercanidipine is a calcium channel blocker of the dihydropyridine class. It is commonly used for the treatment of hypertension. It lowers the blood pressure and allows the heart to work more efficiently. Valsartan is angiotensin II receptor antagonist, a selective for the type I angiotensin receptor. Combination therapy of Lercanidipine and Valsartan had been proven to be more effective than monotherapy in terms of reduction of blood pressure. This paper provides a crtitical review on the methodologies available for determination of Lercanidipine and Valsartan in different pharmaceutical dosage forms. The review highlights a variety of analytical techniques such as UV- Spectroscopy, HPLC (High Performance Liquid Chromatography), HPTLC (High Performance Thin Layer Chromatography), LC (Liquid Chromatography) for the analysis of Lercanidipine and Valsartan.