Male reproductive health has deteriorated significantly in the last few decades. Nutritional, socioeconomic way of life and environmental factors (among others) have been attributed to compromising male reproductive health. In recent years, a large volume of evidence has accumulated suggesting that the trend of declining male fertility (in terms of sperm count, quality and other changes in male reproductive health) might be due to exposure of environmental toxicants. Current study was framed to explore the toxicological effect of sub-lethal concentrations of paraquat (Herbicide) on biochemical and histopathological parameters of male mice Mus musculus and protective role of Ginger (Zingiber officinale) against paraquat toxicity. During the present study it was found that the protective effect of ginger extract against testicular damage induced by paraquat may be attributed to its antioxidant properties.