The most common gynecological ailment is waram-e-rahem in the form of pelvic inflammatory disease (PID) in more than 50% of reproductive age women. In almost all classical and current Unani literature, various Unani Drug Dosage Forms (UDDFs) have been mentioned for the treatment of warm-e-rahem and they have found various disadvantages. Thus, a new dosage form was designed to overcome disadvantages of existing Unani dosage form. The ingredients of Unani Mucoadhesive Vaginal Tablet (UMVT) were Tukhm-e-Khatmi (Althaea officinalis), Tukhm-e-Kanocha (Phyllanthus maderaspatensis), Tukhm-e-Katan (Linum usitassimum), Tukhm-e-Hulba (Trigonella foenum-graecum), Tukhm-e-Makoy (Solanum nigrum), Asapghol (Plantago ovata) and Murdarsang (Plumbi monoxidum). The UMVT was prepared by wet granulation method and evaluated for organoleptic characteristics and other physico-chemical properties, such as weight variation, thickness or diameter, friability, pH of 1% and 10% solutions, hardness disintegration time, dissolution time. The weight determined as per Indian Pharmacopoeia (IP) 2007 was 1000 mg. The UMVT had thickness of 0.6 cm and optimum compactness was found. The mean value of pH 1% & pH 10% of UMVT were 5.67 ± 0.15 and 5.77 ± 0.15, respectively. The mean value of hardness test and disintegration time test of UMVT were 1.73 ± 0.3 and 0.027 ± 0.0058, respectively. The highest Swelling Index of UMVT was found having sodium alginate and chitosan. In vitro mucoadhesive test on UMVT showed the highest mucin binding.