Current century witness antibiotic resistance is becoming a major challenge to the global health care, particularly in the treatment of infectious diseases. A rational approach to deal with antibiotic resistance problems requires detailed knowledge of the different biological and non-biological factors that affect the rate and extent of resistance development. The dire need of health organizations and pharmaceutical industries all over the world to discover and production of more synthetic antibiotics against the fast growing antibiotics-resistant microorganisms, while there are significant alternative sources of natural antimicrobials from plants with different mode of actions, some of them are employed in traditional medicine for centuries and was found to have competitive effects compared to some commercial antibiotics. The available literature shows the potentiality of phytochemicals as effective antibacterial substances that could set off modern antibiotics and later reduce the bacterial resistance to antibiotics.