Formulation and evaluation of SMEDDS containing ezetimibe by employing coconut oil as oil and tween 80, peg 400 as surfactant system
P Tripura Sundari, P Mounika
Solubility is the important process for most of the drug to solubilize in a given solvent to give homogenous solution. The greater the solubility of drug, the greater will be the systemic dissolution showing desired pharmacological response. New techniques have been developed to improve the solubility rate of poorly soluble drugs. Solid dispersion, Complexation, Particle size reduction, co-solvency, etc. Among which, a recent approach lipid base formulations (SMEDDS) are attracting the formulation scientists. These lipid based formulations include SMEDDS, SNEDDS. SMEDDS are nothing but the emulsion containing oil, surfactant, co-surfactant and drug which form oil in water emulsion upon mild agitation with aqueous phase. In the present study SMEDDS containing Ezetimibe, a BCS class II drug is formulated. As Ezetimibe is insoluble in water, lipid based formulations SMEDDS are developed by employing Coconut as lipid phase, Tween 80, PEG400 were selected as surfactant mixture. The better formulations were selected based on the evaluation parameters like drug content, %transmittance, drug release studies.
P Tripura Sundari, P Mounika. Formulation and evaluation of SMEDDS containing ezetimibe by employing coconut oil as oil and tween 80, peg 400 as surfactant system. International Journal of Research in Pharmacy and Pharmaceutical Sciences, Volume 3, Issue 4, 2018, Pages 13-21