A simple, precise, accurate and economic simultaneous UV spectrophotometric method has been developed for the estimation of Amlodipine Besylate and Valsartan in combination in bulk and tablet. The estimation was based upon measurement of absorbance at absorbance maxima of (λ_max) 230-240 nm for Amlodipine Besylate (API) and 240-260 nm for Valsartan (API) in Ethanol : Distilled Water (1:1 ratio) as a solvent respectively in bulk mixture and tablet C. The Beer Lambert’s law obeyed in the concentration range 5-25 µg/ml, 10-50 µg/ml for Amlodipine Besylate and Valsartan, respectively. The estimation of bulk mixture and tablet was carried out by simultaneous equation, Q-analysis and area under curve method for estimation of Amlodipine Besylate & Valsartan. Method was validated with respect to specificity, linearity, range, accuracy, precision, Limit Of Detection, Limit Of Quantitation. Validation was performed as per ICH guidelines the results were found out to be for Amlodipine Besylate and Valsartan. (as per label claim). Comparative Study was done using Five Different Marketed Preparation (Tablet) Containing Amlodipine Besylate and Valsartan. (Amlopress VL (5/80): Cipla Ltd, Exforge (5/80) : Novartis Pharmaceutical Ltd, Amlosartan (5/80): Incepta Pharma Ltd, Amlovas VS (5/80) :Popular Pharma Ltd, AV (5/80) : Drug International Ltd).