ARCHIVES
VOL. 4, ISSUE 2 (2019)
Formulation and evaluation of fast dissolving tablets of cinnarizine using various superdisintegrants
Authors
Injamamul Haque, KJ Hanumanthachar, Chaithanya AN, Subhajit Ghosh
Abstract
The aim of this study was to develop fast dissolving tablets of cinnarizine by direct compression method. Micro crystalline cellulose (MCC) as diluent and super disintegrants, such as crospovidone (CP), sodium starch glycolate and croscarmellose sodium (CCS) were used. Fast dissolving tablets disintegrates or dissolves rapidly within few seconds due to maximized pore structure in the formulation or by the action of superdisintegrants. Infrared (IR) spectroscopy was performed to identify the physicochemical interaction between drug and polymer. IR spectroscopy showed that there was no interaction of drug with polymer. Various pre-compression parameters such as angle of repose, bulk density, tapped density, compressibility index, Hausner’s ratio were carried out to study the flow properties of powder in order to achieve uniformity of tablet weight and the values were found within acceptable limits. The powder mixtures were compressed into tablet using punch tablet machine. The formulated tablets were evaluated for hardness, thickness, weight variation, friability,% drug content, wetting time, water absorption ratio, in vitro disintegration time, in vitro dispersion time, in vitro drug release and all the values were found within permissible limits. The formulation M12 containing crospovidone (8%) as superdisintegrant and MCC as diluent was found to be the optimized formulation on the basis of wetting time, in vitro disintegration time and in vitro drug release. Stability studies were carried out at 250C ± 20C / 60% ± 5% RH and 400C ± 20C / 75% ± 5% RH for a period of 60 days for the selected formulations.
Download
Pages:34-39
How to cite this article:
Injamamul Haque, KJ Hanumanthachar, Chaithanya AN, Subhajit Ghosh "Formulation and evaluation of fast dissolving tablets of cinnarizine using various superdisintegrants". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 4, Issue 2, 2019, Pages 34-39
Download Author Certificate
Please enter the email address corresponding to this article submission to download your certificate.

