Amlodipine besylate is a long acting calcium channel blocker, hydrochlorothiazide is a calcium–sparing diuretic and telmisartan belongs to class of medicines called angiotensin II receptor antagonists. Combination of these drugs has been recently launched for the treatment of hypertension. Hence an attempt has been made to develop and validate an unsophisticated and accurate reverse phase high pressure liquid chromatography (RP-HPLC) method for the simultaneous estimation of Hydrochlorothiazide, Amlodipine and Telmisartan in tablet dosage form. In RP-HPLC method, the wavelength selected for the analysis was 238 nm for Hydrochlorothiazide, Amlodipine and Telmisartan. The solvent used was methanol. The mobile phases used in RP-HPLC were ammonium acetate buffer (adjusted to pH 5.5) and methanol (30:70, v/v). Column used in RP-HPLC was LichroCART @ 250-4Lichrosphere®100RP-18e (5µm) with flow rate of 1ml/min. Retention time (R_t) for hydrochlorothiazide, telmisartan and amlodipine was found to be 2.3 min, 5.3 min and 10.0 min respectively. The validation of the developed method was carried out for various parameters like linearity, accuracy, limit of detection (LOD), limit of quantification (LOQ), precision, specificity and stability studies as per ICH guidelines.