The study was undertaken to determine the pharmacokinetics of ceftiofur after single intramuscular (i/m) injection in local goat of Assam. An injectable commercial preparation of ceftiofur was injected at the dose rate of 2.2 mgkg^-1 body weight by i/m route in each of six male local goats (Capra hircus) of Assam. Bioavailability (F) of 81.90 ± 3.427% was achieved after the administration of the drug. AUC was found to be 345.647 ± 15.395 µgmlÖ¾¹.min.Mean absorption half-life (t_1/2Ka) of 9.803 ± 0.599 min was achieved indicating good absorption rate of the drug.