Considering that most inflammatory diseases occur locally and near the body surface, transdermal drug delivery of non- steroidal anti – inflammatory drug (NSAIDs) may be an interesting strategy for delivering these drugs directly to the diseased site. Naproxen, a potent non-Steroidal anti-inflammatory drug (NSAID) inhibits arachidonic acid metabolism by cyclo-oxygenase and lipo-oxygenase. The compound has been widely used in the treatment of rheumatoid arthritis, osteoarthritis, as well as a mild to moderate painkiller. In these study naproxen transdermal patches were prepared by solvent evaporation method using polymer HPMC and PEG 400.Propylene Glycol used as plasticizer. The prepared patches will evaluated for thickness, folding endurance, tensile strength, flatness, drug content uniformity, In-vitro permeation study, In-vitro release study was performed by using Franz-diffusion cell.