Synthesis and characterisation of pyrazole derivatives from para bromo benzoic acid and its antibacterial activity
Arathi Prakash, Jessy Jacob
Pyrazole is an organic compound with the formula C3H3N2H. It is a heterocycle characterized by a 5-membered ring of three carbon atoms and two adjacent nitrogen atoms. Numerous pyrazole derivatives have been found to possess a broad spectrum of biological activities like anti-bacterial, anti-convulsant, analgesic, anti-microbial, anti-inflammatory, anti-diabetic, sedative anti-rheumatic, anticancer, and anti-tubercular activities. The compounds were synthesized by the normal conventional technique in the lab. All the synthesized compounds were screened for antibacterial activities at three different concentrations (100µg/ml, 250µg/ml, 500µg/ml) against Pseudomonas aeruginosa (Gram –ve) and Bacillus subtilis (Gram + ve) by cup plate agar diffusion method and MIC was found out.
Arathi Prakash, Jessy Jacob. Synthesis and characterisation of pyrazole derivatives from para bromo benzoic acid and its antibacterial activity. International Journal of Research in Pharmacy and Pharmaceutical Sciences, Volume 4, Issue 3, 2019, Pages 40-43