Objective: The main aim of this current research study was to test the effect of valsartan on some renal function parameters (RFPs) in some hypertensive patients. Materials and Methods: This study was conducted in Nablus Hospital, Department of Internal Medicine, Mosul, Iraq, on 20 hypertensive patients. They were recruited and investigated for RFPs, which include: blood urea, serum creatinine, creatinine clearance, serum Na⁺, and serum K⁺. The patient (valsartan) group was followed-up for 8 weeks, during which RFPs were measured before starting therapy and at the end of the follow-up period using commercially available kits. The patient group was compared with a control group consisted of 30 healthy subjects. Results: The RFPs at baseline (before valsartan administration) in the patient group were found elevated as compared to the control group (p<0.001), except for serum K⁺ concentration, which was comparable. The RFPs in the patient group were similar before and after therapy. Conclusion: The use of valsartan for 8 weeks in some hypertensive patients had no adverse effects on RFPs.