With 70% gene similarity to that of human diseased gene, Zebrafish is an aquatic vertebrate which has been presenting innovative ways for pharmacological research on human disease since it was first used in 1960s. This review gives an account on the use of various zebrafish models for disease, their developmental procedure and brief idea on related issues. Different models on adult and larval zebrafish are discussed in this review: Nootropic study with various behavioural models with respect to process of memory and learning, Epileptic model with various seizure inducing methods, metabolic disease like zebrafish obesity, diabetes in zebrafish, atherosclerosis model, fatty-liver disease model and account on cancer mode establishment and tuberculosis study by using Mycobacterium marinum, which causes infection in adult and larva zebrafish as Mycobacterium tuberculosis causes infections in humans. Few Transgenic, Mutant, genetically Knockout or modified zebrafish models are also discussed in above diseases. We conclude that zebrafish is expected to take lead role as a research model in the next some years due to its compelling advantages. However, this would require authentication and simplification of models and their procedures.