Evaluation of Antidiarrhoeal, Antinociceptive and Anti-Inflammatory activity of Centella asiatica in rats
Sanjesh Kumar, Mansi Singh
Pain is a warning sensation, defensive in nature but causes uneasiness. Inflammation is accompanied by pain, stiffness and swelling or oedema of the affected area. Diarrhoea is too frequent passage of watery faeces. The present study investigated the potency of the ethanolic extract of Centella asiatica in the above described disorders in the dose dependent manner. The animals were divided into four groups for each test with 6 rats in each group and tagged properly. Castor oil induced diarrhoea model was used for the study of antidiarrhoeal effect of the drug (p<0.05). The basal reaction time of the rats increased by the extract in hot plate test for antinociception. The ethanolic extract of the Centella asiatica was administered to the rats at doses of 200mg/kg and 400mg/kg for the antidiarrhoeal and antinociceptive activity (p<0.05) significantly reduced the watery faeces and pain in the rats when compared with the control group. The extract at the doses of 100mg/kg and 200mg/kg significantly reduced the inflammation in carragenan induced inflammation in rats (p<0.001) when compared with the control group. The results significantly depicted the antidiarrhoeal, antinociceptive and anti-inflammatory activity of the Centella asiatica extract but in the dose dependent manner, which supports its use as a remedy in these disorders.
Sanjesh Kumar, Mansi Singh. Evaluation of Antidiarrhoeal, Antinociceptive and Anti-Inflammatory activity of Centella asiatica in rats. International Journal of Research in Pharmacy and Pharmaceutical Sciences, Volume 4, Issue 5, 2019, Pages 18-23