Oral controlled release (CR) dosage forms (DFs) have been developed over the past three decades due to their considerable therapeutic advantages such as ease of administration, patient compliance and flexibility in formulation. Drug bioavailability of oral dosage forms is subjective by various factors. One of the significant factor is a gastric residence time (GRT) of these dosage forms. Gastro retentive dosage form can remain in the gastric region for several hours and hence significantly prolong the gastric residence time of drugs. Prolonged gastric retention improves bioavailability, reduces drug waste, and improves solubility of drugs that are less soluble in a high pH environment. The need for gastroretentive dosage forms (GRDFs) has led to extensive efforts in both academia and industry towards the development of such drug delivery systems.
Saumya Shrivastava, Deepak Kumar, Rahul Ancheria, Shankar Lal Soni, Mukesh Sharma. Preparation and In-vitro evaluation of gelucire based gastric floating beads of ofloxacin. International Journal of Research in Pharmacy and Pharmaceutical Sciences, Volume 4, Issue 6, 2019, Pages 08-14