A cancer diagnosis is life‑changing, and is a source of considerable psychological and emotional stress and it generates a higher sense of distress than non-neoplastic diseases. The purpose of this study was to analyze the prevalence of depression in cancer patients using Beck Depression Inventory II (BDI-II). We evaluated the prevalence of depression with Beck Depression Inventory (BDI) scale in 200 patients undergoing chemotherapy during our study period of 6 months. To assess the severity of depression, Beck Depression Inventory questionnaire was given to each patient in a language understandable to them. (English/Malayalam) which was voluntarily filled by the patient. Among the 200 study subjects enrolled cancer was more prevalent in the age group of 68- 77 years, majority of the patients were moderately depressed. Among the moderately depressed patients, majority were females. Higher rate of depression in females may be because women share many risk factors for depression. Providing proper patient counseling and improving their awareness about the disease and therapy can help reduce the rates of depression.