Aims: This study was aimed to evaluate the antimicrobial activity, and antioxidant profile of different extracts of tender leaf part of Grewia tiliifolia Vahl which are commonly used in Ayurveda drug preparations. Methodology: Tender leaf part of G. tiliifolia subjected to analyze the antioxidant potential by various methods, such as DPPH, ABTS and Ferrous ion chelating assay further, to assess the in vitro antimicrobial activity of Grewia species by using disc diffusion method against different microorganisms. Results: The results of the present investigation revealed that higher levels of chelating ability for ferrous ions was observed in the crude ethyl acetate extract of tender leaves of G.tiliifolia. Methanol extract also exhibited maximum antioxidant activity in DPPH and ABTS^•+ assays. The antimicrobial activity showed the highest zone of inhibition in chloroform extract. Conclusion: Tender leaves of the species which exhibited well marked antioxidant and antimicrobial activity.