The recent advance in nanotechnology has led to the improvement of targeted drug delivery system by targeting a molecule to a particular site using specialized drug delivery system. The nanosponges are solid in nature and can be formulated to various dosage forms. For the oral administration, the complexes may be dispersed in a matrix of excipients, diluents suitable for the preparation of capsules or tablets. To achieve a better dissolution and bioavailability of poorly water insoluble drugs, it is necessary to select the best technique for the preparation of nanosponges for controlled drug delivery. This is influenced by a number of factors like Drug release (DR), Drug stability (DS) etc. The study was conducted using five alternatives to select the right decision for achieving the goal. The overall ranking of all techniques are selected based on priority ranking shows that Emulsion solvent evaporation technique is the most suitable method.